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N of this entire area in unfused (UF) myoblasts, fused (F) myotubes and PBMCs (Figure 1). The peaks of enrichment of H3 lysine acetylation throughout the region analysed corresponded to the TSS of most of the genes including DES (Figure 1A). The DES LCR was enriched for H3 acetylation approximately 2? fold above non-muscle PBMCs in both myoblasts and myotubes (Figure 1A and Additional file 1, Fig
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Ctive, with favorable clinical response rates (i.e., cure rates) of 80 at the TOC visit, 150 subjects per treatment group were required to ensure with 90 power that the lower bound of a two-sided 95 confidence interval (CI) for the true difference in efficacy (tigecycline minus comparator) corrected for continuity did not exceed -15 . The noninferiority of tigecycline compared with comparator
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